GSK、抗BCMA ADCを申請／HIF-2α阻害薬ベルズチファン、VHL病関連腫瘍でも申請など｜製薬業界きょうのニュースまとめ読み（2024年9月17日）

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hif: GSK、抗BCMA ADCを申請／HIF-2α阻害薬ベルズチファン、VHL病関連腫瘍でも申請など｜製薬業界きょうのニュースまとめ読み（2024年9月17日）

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2024-09-03 07:00 Citrullination modulation stabilizes HIF-1α to promote tumour progression - Nature.com
2024-09-24 07:00 A nature-inspired HIF stabilizer derived from a highland-adaptation insertion of plateau pika Epas1 protein - ScienceDirect.com
2024-05-16 07:00 HIF Global selects Johnson Matthey’s methanol technology for the largest e methanol plant in South America - Johnson Matthey
2024-09-20 07:00 MOL Invests in HIF Global, a U.S.-based company of e-Fuels -Toward the Decarbonization of the Mobility Industry with synthetic fuels - - 株式会社商船三井
2024-10-21 07:00 Discovery of ZG-2305, an Orally Bioavailable Factor Inhibiting HIF Inhibitor for the Treatment of Obesity and Fatty Liver Disease - ACS Publications
2024-09-11 07:00 HIF-2α drives hepatic Kupffer cell death and proinflammatory recruited macrophage activation in nonalcoholic steatohepatitis - Science
2024-06-26 07:00 A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity - Wiley Online Library
2024-09-14 07:00 HIF-2α- dependent induction of miR-29a restrains T - Nature.com
2024-05-31 20:06 Stilbenoid derivatives as potent inhibitors of HIF-1α-centric cancer metabolism under hypoxia - ScienceDirect.com

2024-08-28 07:00 Pharmacologic HIF stabilization activates costimulatory receptor expression to increase antitumor efficacy of adoptive T cell therapy - Science
2024-06-27 07:00 Targeting HIF-1 to treat AML - Nature.com
2024-02-27 08:00 The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation - ScienceDirect.com
2024-07-24 07:00 HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma - Nature.com
2024-05-16 02:04 HIF-1α Mediates Immunosuppression and Chemoresistance in Colorectal Cancer by Inhibiting CXCL9, −10 and −11 - ScienceDirect.com
2024-11-16 08:00 Catalpol regulates apoptosis and proliferation of endothelial cell via activating HIF-1α/VEGF signaling pathway - Nature.com
2024-04-18 07:00 The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia - Nature.com
2024-09-19 07:00 The p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma - Nature.com
2024-03-12 07:00 The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair | Bone Research - Nature.com
2024-11-25 08:00 FBP1 over-expression suppresses HIF-1α in papillary thyroid cancer - Nature.com

2024-06-04 07:00 Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α - Nature.com
2024-11-23 08:00 Association of serum HIF-1α levels with coronary artery calcification in patients of non-dialysis chronic kidney disease - Nature.com
2024-09-11 12:16 Recombinant canstatin inhibits the progression of hepatocellular carcinoma by repressing the HIF-1α/VEGF signaling pathway - ScienceDirect.com
2024-07-03 23:12 Immunometabolism and Sepsis: A Role for HIF? - Frontiers
2024-06-25 03:45 Increased HIF-2α activity in the nucleus pulposus causes intervertebral disc degeneration in the aging mouse spine - Frontiers
2024-11-15 08:00 HIF-1α knockdown attenuates phenotypic transformation and oxidative stress induced by high salt in human aortic vascular smooth muscle cells - Nature.com
2024-05-15 07:00 Cholesterol accumulation impairs HIF-1α-dependent immunometabolic reprogramming of LPS-stimulated macrophages by upregulating the NRF2 pathway - Nature.com
2024-02-13 08:00 Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin - Nature.com
2024-08-22 07:00 From Bench to Bedside: HIF-2α Inhibition in RCC - OncLive
2024-08-06 07:00 Hif-2α programs oxygen chemosensitivity in chromaffin cells - JCI

2024-03-19 07:00 MOL, Idemitsu, HIF Team up to Develop e-fuel/e-methanol Supply Chain, Including Marine Transport of CO - 株式会社商船三井
2024-11-14 08:00 Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation - Nature.com
2024-10-25 18:29 Exploration the mechanism underlying protocatechuic acid in treating osteoporosis by HIF-1 pathway based on network pharmacology, molecular docking, molecular dynamics simulation and experimental verification - ScienceDirect.com
2024-06-05 07:00 HIF-1α and MIF enhance neutrophil-driven type 3 immunity and chondrogenesis in a murine spondyloarthritis model - Nature.com
2024-10-17 07:00 Genistein inhibits HIF-1α and attenuates high glucose-induced peritoneal mesothelial-mesenchymal transition and fibrosis via the mTOR/OGT pathway - Nature.com
2024-08-23 07:00 LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia - Nature.com
2024-06-26 07:00 A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity - Wiley Online Library
2024-05-02 07:00 NREP, transcriptionally upregulated by HIF-1α, aggravates breast cancer cell growth and metastasis by promoting glycolysis - Nature.com
2024-09-15 07:00 NKT-2152: A Promising HIF-2α Inhibitor in ccRCC - Targeted Oncology
2024-10-04 07:00 MDM2 induces pro-inflammatory and glycolytic responses in M1 macrophages by integrating iNOS-nitric oxide and HIF-1α pathways in mice - Nature.com

2024-11-11 08:00 Abstract 4138199: Examining the regulating mechanism of the HIF-FOXM1 axis in promoting adult pig cardiomyocyte proliferation - AHA Journals
2024-05-06 07:00 HIF-1α participates in the regulation of S100A16-HRD1-GSK3β/CK1α pathway in renal hypoxia injury - Nature.com
2024-07-31 07:00 Monitoring imatinib decreasing pericyte coverage and HIF-1α level in a colorectal cancer model by an ultrahigh-field multiparametric MRI approach - Journal of Translational Medicine
2024-04-04 07:00 Hypoxic preconditioning accelerates the healing of ischemic intestinal injury by activating HIF-1α/PPARα pathway-mediated fatty acid oxidation - Nature.com
2024-07-01 07:00 Activation of the osteoblastic HIF-1α pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegIIIγ - Nature.com
2024-05-10 07:00 An investigation into the HIF-dependent intestinal barrier protective mechanism of Qingchang Wenzhong decoction in ulcerative colitis management - ScienceDirect.com
2024-05-13 07:00 Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner - Nature.com
2024-03-01 08:00 Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer - Nature.com
2024-08-09 07:00 HIF Global’s eFuels portfolio receives $36 million boost from JOGMEC - Offshore Energy
2024-07-20 18:22 Jianwei Xiaoyan granule ameliorates chronic atrophic gastritis by regulating HIF-1α-VEGF pathway - ScienceDirect.com

2024-08-26 07:00 Letter by Sun and Ren Regarding Article, “MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy” | Circulation - AHA Journals
2024-06-27 08:52 The Roles of HIF-1α in Radiosensitivity and Radiation-Induced Bystander Effects Under Hypoxia - Frontiers
2024-05-29 07:00 Design and Synthesis of Quinoxaline Hybrids as Modulators of HIF-1a, VEGF, and p21 for Halting Colorectal Cancer - ACS Publications
2024-06-26 21:07 Regulation of the SIAH2-HIF-1 Axis by Protein Kinases and Its Implication in Cancer Therapy - Frontiers
2024-05-01 07:00 Glutamine-derived aspartate is required for eIF5A hypusination-mediated translation of HIF-1α to induce the polarization of tumor-associated macrophages - Nature.com
2024-10-14 07:00 Unveiling the proteome of the fasting heart: Insights into HIF-1 pathway regulation - Frontiers
2024-02-14 06:18 Safety of HIF prolyl hydroxylase inhibitors for anemia in dialysis patients: a systematic review and network meta-analysis - Frontiers
2024-04-22 07:00 MED15 is upregulated by HIF-2α and promotes proliferation and metastasis in clear cell renal cell carcinoma via activation of SREBP-dependent fatty acid synthesis - Nature.com
2024-09-14 07:00 ESMO 2024: Dr. Jonasch on implications of positive HIF-2α inhibitor data in ccRCC - Urology Times
2024-07-23 07:00 HIF Global signs collaboration agreement with Airbus for Sustainable Aviation Fuels - PR Newswire

2018-06-29 07:00 Hamilton's future secured - Hamilton City Council
2024-01-23 08:00 Factor inhibiting HIF negatively regulates antiviral innate immunity via hydroxylation of IKKϵ - ScienceDirect.com
2024-02-10 15:52 HIF-1α/m6A/NF-κB/CCL3 axis-mediated immunosurveillance participates in low level benzene-related erythrohematopoietic development toxicity - ScienceDirect.com
2024-05-17 07:54 Exploring the Role of HIF-2α Inhibition in Advanced Clear Cell Renal Cell Carcinoma - ASCO Daily News
2024-06-17 07:00 HIF- 2α expression and metabolic signaling require ACSS2 in clear cell renal cell carcinoma - JCI
2024-02-08 18:56 HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons - Frontiers
2024-02-16 08:00 HIF-2α-dependent TGFBI promotes ovarian cancer chemoresistance by activating PI3K/Akt pathway to inhibit apoptosis and facilitate DNA repair process - Nature.com
2024-09-19 07:00 Latham & Watkins Advises HIF Global on Investment by MOL - Latham & Watkins LLP
2024-04-15 07:00 Mitochondrial dysfunction induced by HIF-1α under hypoxia contributes to the development of gastric mucosal lesions - Wiley Online Library
2024-01-20 08:00 Linking HIF oxygen-sensing system diversity to hypoxia fitness in Eleutheronema: Molecular characterization and transcriptional response to hypoxia exposure - ScienceDirect.com

2024-10-24 07:00 Arcus' new HIF-2a data in kidney cancer hint at potential edge over Merck's Welireg, analysts say - Fierce Biotech
2024-02-16 03:33 Hypoxia-Inducible Factor (HIF) as a Target for Novel Therapies in Rheumatoid Arthritis - Frontiers
2024-02-11 17:13 HIF-1α Stabilization Increases miR-210 Eliciting First Trimester Extravillous Trophoblast Mitochondrial Dysfunction - Frontiers
2024-07-11 01:22 Editorial: The Development of New Classes of Hypoxia Mimetic Agents for Clinical Use - Frontiers
2024-04-25 07:00 HIF-PH Inhibitors for Anemia in CKD - DocWire News
2024-08-13 07:00 Latham Watkins Advises HIF Global on US36 Million Equity Investment Japan Organization Metals Energy - Latham & Watkins LLP
2024-02-13 08:16 Ginsenoside Compound K Regulates HIF-1α-Mediated Glycolysis Through Bclaf1 to Inhibit the Proliferation of Human Liver Cancer Cells - Frontiers
2024-02-20 02:32 Integrative analyses identify HIF-1α as a potential protective role with immune cell infiltration in adamantinomatous craniopharyngioma - Frontiers
2024-03-19 07:00 MOL, HIF and Idemitsu team up on eFuels supply chain and CO2 marine transport - Offshore Energy
2024-02-05 22:43 Twin Resemblance in Muscle HIF-1α Responses to Hypoxia and Exercise - Frontiers

2024-02-15 08:00 PX-478, an HIF-1α inhibitor, impairs mesoCAR T cell antitumor function in cervical cancer - Frontiers
2024-02-07 13:42 Interleukin-15 Signaling in HIF-1α Regulation in Natural Killer Cells, Insights Through Mathematical Models - Frontiers
2024-06-26 09:25 α-Lipoic Acid Maintains Brain Glucose Metabolism via BDNF/TrkB/HIF-1α Signaling Pathway in P301S Mice - Frontiers
2024-01-10 08:00 Salvianolic acid A attenuates arsenic-induced ferroptosis and kidney injury via HIF-2α/DUOX1/GPX4 and iron homeostasis - ScienceDirect.com
2024-01-09 08:00 Hsa_circ_0081065 exacerbates IH-induced EndMT via regulating miR-665/HIF-1α signal axis and HIF-1α nuclear translocation - Nature.com
2024-02-15 23:16 Glycolytic Response to Inflammation Over Time: Role of Myeloid HIF-1alpha - Frontiers
2024-02-05 11:44 Acetate Improves the Killing of Streptococcus pneumoniae by Alveolar Macrophages via NLRP3 Inflammasome and Glycolysis-HIF-1α Axis - Frontiers
2024-02-05 08:00 Benefits and Risks of Long-Term Use of HIF-PHIs for Anemia of CKD - DocWire News
2024-02-27 08:00 JFE Steel Corporation - jfe-steel.co.jp
2024-07-09 07:00 New space for innovation: the renovated and extended HIF building of the D-BAUG – Staffnet - ETH Zürich

2024-02-15 07:14 Cobalt Chloride Upregulates Impaired HIF-1α Expression to Restore Sevoflurane Post-conditioning-Dependent Myocardial Protection in Diabetic Rats - Frontiers
2017-11-29 05:52 HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia - ScienceDirect.com
2023-08-09 07:00 Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells - Nature.com
2022-06-20 07:00 The effect of HIF on metabolism and immunity - Nature.com
2016-08-26 07:00 Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases - Nature.com
2017-12-12 04:19 HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption - ScienceDirect.com
2022-10-08 07:00 HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis | Cell Death & Disease - Nature.com
2020-01-31 08:00 Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model - Nature.com
2024-08-14 07:00 USGS, UA Celebrate Opening of World-Class Hydrologic Facility - UA News Center
2023-11-23 08:00 Long-term HIF-1α stabilization reduces respiration, promotes mitophagy, and results in retinal cell death - Nature.com

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hif, GSK、抗BCMA ADCを申請／HIF-2α阻害薬ベルズチファン、VHL病関連腫瘍でも申請など｜製薬業界きょうのニュースまとめ読み（2024年9月17日） 2022 hif

GSK、抗BCMA ADCを申請／HIF-2α阻害薬ベルズチファン、VHL病関連腫瘍でも申請など｜製薬業界きょうのニュースまとめ読み（2024年9月17日）

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GSK、抗BCMA ADCを申請／HIF-2α阻害薬ベルズチファン、VHL病関連腫瘍でも申請など｜製薬業界きょうのニュースまとめ読み（2024年9月17日）

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